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May 15, 2024Open Access

Quantitative and systematic NMR measurements of sequence-dependent A-T Hoogsteen dynamics uncovers unique conformational specificity in the DNA double helix

Akanksha Manghrani Atul Rangadurai Or Szekely Bei Liu Serafima Guseva Hashim M. Al‐Hashimi

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Abstract

The propensities to form lowly-populated short-lived conformations of DNA could vary with sequence, providing an important source of sequence-specificity in biochemical reactions. However, comprehensively measuring how these dynamics vary with sequence is challenging. Using

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Manghrani et al. (2024) studied this question.

synapsesocial.com/papers/68e6a14db6db643587625327 https://doi.org/10.1101/2024.05.15.594415

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