Neurological soft signs are non-localizing neurological abnormalities that cannot be related to the impairment of a specic brain region or are not believed to be part of a well-dened neurological syndrome. They were observed in schizophrenia and other psychiatric disorders. Neurological soft signs are here reviewed regarding cannabis use, obstetrics complications, antipsychotic treatments and the potential use of neurological soft signs as candidate endophenotypes for schizophrenia. Neurological soft signs emerge as a potential endophenotype for several disorders rather than a specic endophenotype for schizophrenia. There are no important correlations between neurological soft signs and obstetric correlations and neuroleptic treatment. Cannabis abuse could be associated with the development of neurological soft signs.
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Marini et al. (2024) studied this question.
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