RETROSPECTIVE ANd PROSPECTIVE STUDY OF CLINICOPATHOLOGICAL EVALUATION AND MANAGEMENT OF GESTATIONAL TROPHOBLASTIC DISEASE

GTD is spectrum of cellular proliferation disorder where trophoblast undergoes hydropic degeneration with or without invasion, hydropic uid is rich in hCG. It can be complete mole or partial mole depending on presence of fetal tissue and in absence of invasion. if invasion is detected it can be invasive mole, choriocarcinoma, epithelioid trophoblastic tumor (ETT), 1 placental site trophoblastic tumor (PSTT) , Invasive disease & PSTT are collectively called GTN. Earlier when means of diagnosis and chemotherapy were not present GTD used to carry very high mortality. Since the advent of USG to help early diagnosis and good facilities for surgical evacuation it has become easily managable condition while at same time advent of Chemotherapy has made choriocarcinoma one of the most curable tumors even with distant metastasis. β Hcg is very Important biochemical marker for diagnosis and 2 monitoring of GTD. USG & β-HCG makes mainstay for diagnosis, follow up and early detection of persistence of disease. In case of GTN multispecialty management is required. As GTN may arise after any pregnancy being it H.Mole, normal or abortion making β- hcg an important element of follow up , though GTN may arise at any age but extremes of age favor it, in this study we aim to identify epidemiological factors which increase chances of GTD as well as role of follow up in early diagnpsis and treatment of GTN