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May 14, 2024Journal of Medicinal Chemistry

Structure–Activity Relationships toward the Identification of a High-Potency Selective Human Toll-like Receptor-7 Agonist

Deepender Kaushik Arshpreet Kaur Madhuri T. Patil Binita Sihag Sakshi Piplani Isaac G. Sakala Yoshikazu Honda‐Okubo Saravanan Ramakrishnan Nikolai Petrovsky Deepak B. Salunke

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Abstract

Toll-like receptor (TLR)-7 agonists are immunostimulatory vaccine adjuvants. A systematic structure-activity relationship (SAR) study of TLR7-active 1-benzyl-2-butyl-1

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Kaushik et al. (2024) studied this question.

synapsesocial.com/papers/68e6a284b6db643587626072 https://doi.org/10.1021/acs.jmedchem.4c00464

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Structure−Activity Relationships Towards the Identification of High-Potency Selective Human Toll-Like Receptor-7 Agonist2024 · 1 citations
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5Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody–Drug Conjugate Payloads2024 · 13 citations

Discovery of Two Potential and Novel Toll-like Receptor 7 Antagonists via Molecular Docking, Molecular Dynamics Simulation and In Vitro Biological Evaluation2026
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