May 14, 2024International Journal of Molecular SciencesOpen Access

Blap-6, a Novel Antifungal Peptide from the Chinese Medicinal Beetle Blaps rhynchopetera against Cryptococcus neoformans

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Authors

LZLamei ZhangHarbin Institute of Technology SZSheng-Wen ZhouKunming Institute of Zoology XHXiaoshan HuangZhejiang Chinese Medical University

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Overview

In vitro analysis demonstrates that beetle-derived peptide blap-6 inhibits Cryptococcus neoformans and fungal biofilms, highlighting its potential as a safer therapeutic candidate.

Key Points

Blap-6, a novel antimicrobial peptide from beetle hemolymph, exerts potent activity against Cryptococcus neoformans by penetrating and disrupting fungal cell membrane integrity.
A minimum inhibitory concentration of 0.81 μM suppresses fungal growth, while the 17-amino-acid sequence KRCRFRIYRWGFPRRRF also exhibits strong biofilm inhibition activity.
Screening of the Blaps rhynchopetera hemolymph transcriptome identified the sequence, which displayed low cytotoxicity to human cells; in vitro model, further testing needed.

Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e6a293b6db643587626568 https://doi.org/10.3390/ijms25105336

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May 14, 2024International Journal of Molecular SciencesOpen Access

Blap-6, a Novel Antifungal Peptide from the Chinese Medicinal Beetle Blaps rhynchopetera against Cryptococcus neoformans

View Full Paper

Ask AI

Bookmark

Authors

LZLamei ZhangHarbin Institute of Technology SZSheng-Wen ZhouKunming Institute of Zoology XHXiaoshan HuangZhejiang Chinese Medical University

Discussion

Member takes

Overview

In vitro analysis demonstrates that beetle-derived peptide blap-6 inhibits Cryptococcus neoformans and fungal biofilms, highlighting its potential as a safer therapeutic candidate.

Key Points

Blap-6, a novel antimicrobial peptide from beetle hemolymph, exerts potent activity against Cryptococcus neoformans by penetrating and disrupting fungal cell membrane integrity.
A minimum inhibitory concentration of 0.81 μM suppresses fungal growth, while the 17-amino-acid sequence KRCRFRIYRWGFPRRRF also exhibits strong biofilm inhibition activity.
Screening of the Blaps rhynchopetera hemolymph transcriptome identified the sequence, which displayed low cytotoxicity to human cells; in vitro model, further testing needed.

Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e6a293b6db643587626568 https://doi.org/10.3390/ijms25105336

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