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Preclinical study demonstrates antidepressant-like effects of infralimbic cortex activation in an estradiol withdrawal model, suggesting a therapeutic target for postpartum depression.
Clinical and preclinical studies have demonstrated that estradiol withdrawal after delivery is one of important factors involved in the pathogenesis of postpartum depression (PPD). The infralimbic cortex (IL) is related to anxiety and mood disorders. Whether IL neurons mediate PPD is still unclear.
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Chen et al. (2024) studied this question.
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