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May 13, 2024Open Access

Disulfide constrained Fabs overcome target size limitation for high-resolution single-particle cryo-EM

Jennifer E. Kung Matthew C. Johnson Christine C. Jao Christopher P. Arthur Dimitry Tegunov Alexis Rohou Jawahar Sudhamsu

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Abstract

High-resolution structures of proteins are critical to understanding molecular mechanisms of biological processes and in the discovery of therapeutic molecules. Cryo-EM has revolutionized structure determination of large proteins and their complexes

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Cite This Study

Kung et al. (2024) studied this question.

synapsesocial.com/papers/68e6a619b6db643587628e90 https://doi.org/10.1101/2024.05.10.593593

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