⁶⁴Cu Tumor Labeling with Hexadentate Picolinic Acid‐Based Bispidine Immunoconjugates

Bispidine picolinates quickly form very stable complexes with the positron emitter 64CuII under physiological conditions. These bifunctional chelators can be easily attached to amino-terminated tumor-seeking target modules. The subsequent 64Cu labeling is fast and efficient, and does not require demanding purification steps. These compounds have great potential for the development of copper-labeled radiopharmaceuticals. More information can be found in the Research Article by M. Kubeil, P. Comba, H. Stephan and co-workers (DOI: 10.1002/chem.202400366).