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margin of safety, with doses provided by the Penthrox inhaler being far below those needed to produce any renal or hepatic toxicity, and it is used safely within other health care settings.The inhaler design is simple and would not require adaptation of existing dental clinics for its use.Regarding environmental concerns, the activate carbon chamber should prevent environmental release of the drug.No sedative agent is perfect, however, and the disadvantages discussed here must also be considered.More research needs to be undertaken to establish its efficacy in managing dental pain and anxiety to allow for its use alongside dental treatment.Should it be proven effective, methoxyflurane could be a useful and environmentally friendly alternative to N 2 O.
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