⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

May 8, 2024Antioxidants and Redox Signaling

Adenosine A2A Receptor Antagonist Sch58261 Improves the Cognitive Function in Alzheimer’s Disease Model Mice Through Activation of Nrf2 via an Autophagy-Dependent Pathway

Yi Sun Chao Liu Ling He

View at Publisher

Ask AI

Bookmark

Share

Abstract

Adenosine, an important endogenous neuromodulator, contributes to a broad set of several neurodegenerative diseases. The adenosine A2A receptor (A2AR) is the most involved in neuropathological effects and plays an important role in the pathogenesis of Alzheimer's disease (AD). However, the effect of A2AR antagonist and the underlying mechanism in AD model mice remains unclear.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Sun et al. (2024) studied this question.

synapsesocial.com/papers/68e6b029b6db64358763206b https://doi.org/10.1089/ars.2023.0455

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice2024 · 20 citations
2Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockadeOriginal Research · 2005 · 539 citations
3What role does adenosine play in the pathophysiology of Alzheimer's disease?Original Research · 2026
4Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term PotentiationOriginal Research · 2023 · 15 citations
5Genetic deletion of adenosine A2A receptors attenuates memory deterioration and alterations of synaptic plasticity and metabolic controllers in the hippocampus and prefrontal cortex of aged miceOriginal Research · 2026

Neurophysiological In Vitro Model of Amyloid-β-Induced Deficits of Hippocampal LTP Involving Neuronal Adenosine A2A Receptor Dysfunction Through CD732026
Adenosine A2A Receptor Blockade Provides More Effective Benefits at the Onset Rather than after Overt Neurodegeneration in a Rat Model of Parkinson’s Disease2024
Targeting Adenylate Cyclase: A Novel Concept for Stimulation of Neurogenesis and Pharmacotherapy of Alzheimer's Disease2024
The Major Iron Transporter DMT1 Promotes Renal Fibrosis by Activating Ferroptosis and Enforcing TGF-β1 Signaling in Renal Tubular CellsAntioxidants and Redox Signaling · 2026
Is Oxidative Stress–Driven Platelet Activation Associated with Echocardiographic Vegetations in Infective Endocarditis?Antioxidants and Redox Signaling · 2026

More from Antioxidants and Redox Signaling

More from China Pharmaceutical University

More from Xuzhou Medical College