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May 8, 2024European Journal of Inorganic ChemistryOpen Access

Application of Biaryl Phosphacycles in Palladium‐Catalysed Suzuki‐Miyaura Cross‐Coupling Reactions of Aryl Chlorides

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Authors

JLJairus L. LamolaSasol (South Africa)PMPaseka T. MoshapoUniversity of JohannesburgCHCedric W. HolzapfelUniversity of Johannesburg

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Implication

Preclinical analysis demonstrates facile cross-coupling in challenging aryl chlorides, highlighting robust utility of biaryl phosphacycle catalysts.

Key Points

  • Facile Suzuki-Miyaura couplings of deactivated and heteroaryl chloride substrates proceed smoothly using biaryl phosphacycle catalysts.
  • Application of biaryl phosphacycles in palladium catalysis enables cross-coupling of hindered aryl chlorides with partner aryl boronic acids.
  • Highlights the exceptional utility of biaryl phosphacycle ligand 7, which may enable broader synthesis of challenging biaryl architectures.

Cite This Study

Lamola et al. (2024) studied this question.

synapsesocial.com/papers/68e6b030b6db6435876321e1https://doi.org/10.1002/ejic.202400068
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recent Developments in the Suzuki-Miyaura Reaction: 2010–20142015 · 331 citations
  2. 2Synthesis of (MeCN)2Pd(CF3)OTs, a General Precursor to Palladium(II) Trifluoromethyl Complexes LPd(CF3)X2019 · 4 citations
  3. 3Suzuki–Miyaura cross coupling reaction: recent advancements in catalysis and organic synthesis2021 · 212 citations
  4. 4HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium‐Catalyzed Cross‐Couplings in Water at Room Temperature2016 · 166 citations
  5. 5Current Applications of Suzuki–Miyaura Coupling Reaction in The Total Synthesis of Natural Products: An update2018 · 211 citations