Population‐specific validation and comparison of the performance of 77‐ and 313‐variant polygenic risk scores for breast cancer risk prediction

Milena Hovhannisyan; Petra Zemánková; Petr Nehasil; Kateřina Matějková; Marianna Borecká; Marta Černá; Taťána Doležalová; Lenka Dvořáková; Lenka Foretová; Klára Horáčková; Sandra Jelínková; Pavel Just; Marta Kalousová; J Král; Eva Macháčková; Barbora Němcová; Markéta Šafaříková; Drahomíra Springer; Barbora Šťastná; Spiros Tavandzis; Michal Vočka; Tomáš Zima; Jana Soukupová; Petra Kleiblová; Corinna Ernst; Zdeněk Kleibl; Markéta Janatová

doi:10.1002/cncr.35337

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Abstract

The polygenic risk score (PRS) allows the quantification of the polygenic effect of many low-penetrance alleles on the risk of breast cancer (BC). This study aimed to evaluate the performance of two sets comprising 77 or 313 low-penetrance loci (PRS77 and PRS313) in patients with BC in the Czech population.

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Hovhannisyan et al. (2024) studied this question.

synapsesocial.com/papers/68e6b135b6db643587632594 https://doi.org/10.1002/cncr.35337

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Population‐specific validation and comparison of the performance of 77‐ and 313‐variant polygenic risk scores for breast cancer risk prediction

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Population‐specific validation and comparison of the performance of 77‐ and 313‐variant polygenic risk scores for breast cancer risk prediction

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