Three novel dihydrochalcones, flemilineatins C–E (1–3), and two known flavanones (4–5) were isolated from Flemingia lineata (L.) W.T. Aiton leaves. Dihydrochalcones 1–3 structures were established using NMR spectrum and high-resolution ESIMS data. Compounds 1–5 were assayed to Plasmodium falciparum lactate dehydrogenase (PfLDH) for their antiplasmodial activity. Compounds 2 and 5 exhibited high activity with an IC50 value of 0.74 and 0.79 µg/mL, respectively.
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Saputri et al. (2024) studied this question.
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