Teaching an Old Dog New Tricks for Achieving CB₂-Selective Inverse Agonism

ADVERTISEMENT RETURN TO ARTICLES ASAPFirst ReactionsNEXTTeaching an Old Dog New Tricks for Achieving CB2-Selective Inverse AgonismThree laboratories team up to "flip the switch" and turn a CB2R agonist into a fluorescent CB2R inverse agonist.Morgane MandoMorgane MandoDepartment of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United StatesMore by Morgane Mando, Christopher W. Cunningham​Christopher W. CunninghamDepartment of Pharmaceutical Sciences, Concordia University Wisconsin, Mequon, Wisconsin 53097, United StatesEmail: [email protected]More by Christopher W. Cunninghamhttps://orcid.org/0000-0002-4468-2213, and Alexander J. Grenning​Alexander J. GrenningDepartment of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United StatesEmail: [email protected]More by Alexander J. Grenninghttps://orcid.org/0000-0002-8182-9464Cite this: ACS Cent. Sci. 2024, XXXX, XXX, XXX-XXXPublication Date (Web):May 8, 2024Publication History Published online8 May 2024https://doi.org/10.1021/acscentsci.4c00673Published 2024 by American Chemical Society. This publication is licensed under CC-BY 4.0. License Summary*You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters below:Creative Commons (CC): This is a Creative Commons license.Attribution (BY): Credit must be given to the creator.View full license*DisclaimerThis summary highlights only some of the key features and terms of the actual license. It is not a license and has no legal value. Carefully review the actual license before using these materials. This publication is Open Access under the license indicated. Learn MoreArticle Views-Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (1 MB) Get e-Alertsclose Get e-Alerts