Structural mass spectrometry reveals a conserved protective epitope in S. pyogenes Streptolysin O, highlighting viable targets for antibody-guided vaccine design.
An important element of antibody-guided vaccine design is the use of neutralizing or opsonic monoclonal antibodies to define protective epitopes in their native three-dimensional conformation. Here, we demonstrate a multimodal mass spectrometry-based strategy for in-depth characterization of antigen-antibody complexes to enable the identification of protective epitopes using the cytolytic exotoxin Streptolysin O (SLO) from
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Tang et al. (2024) studied this question.
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