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May 2, 2024Clinical Cancer Research8 citationsOpen Access

Minimal Residual Disease using a Plasma-Only Circulating Tumor DNA Assay to Predict Recurrence of Metastatic Colorectal Cancer Following Curative Intent Treatment

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APAparna R. ParikhBCBryant H. CheeJTJill Tsai

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Abstract

Minimal residual disease (MRD) detection can identify the recurrence in patients with colorectal cancer (CRC) following definitive treatment. We evaluated a plasma-only MRD assay to predict recurrence and survival in patients with metastatic CRC who underwent curative intent procedures (surgery and/or radiotherapy), with or without (neo)adjuvant chemotherapy. The primary objective of this study was to assess the correlation of postprocedure tumor cell-free DNA detection status with radiographic disease recurrence.

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Parikh et al. (2024) studied this question.

synapsesocial.com/papers/68e6bbe0b6db64358763cb3fhttps://doi.org/10.1158/1078-0432.ccr-23-3660
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