Abstract World Health Organization estimates that there were over 10 million cases of tuberculosis (TB) worldwide in 2019, resulting in over 1.4 million deaths, with a worrisome increasing trend yearly. The disease is caused by Mycobacterium tuberculosis (MTB) through airborne transmission. Treatment of TB is estimated to be 85% successful, however, this drops to 57% if MTB exhibits multiple antimicrobial resistance (AMR), for which fewer treatment options are available. In this paper, we provide an in-depth look at the genetic basis of MTB antibiotic resistance, using the Bacterial and Viral Bioinformatics Resource Center (BV-BRC) and analyzing over 27,000 MTB genomic strains from the BV-BRC database. Our findings offer a detailed picture of resistance prevalence and AMR gene frequencies, especially for second-line and last-resort antibiotics, contributing valuable insights into MTB AMR mechanics and supporting future research and clinical strategies against MTB.
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Serajian et al. (2024) studied this question.
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