Approach to diagnosis and management of reactivation of chronic hepatitis B

Hepatitis B virus (HBV) reactivation is a condition marked by the return of HBV particles in patients whose HBV has previously cured or by an increase in HBV viremia in individuals whose HBV was previously chronic (CHB). Immunosuppressive treatments are more frequently the cause of reactivation; however, it can happen on its own. Reactivation can result in severe morbidity and death, but it can be avoided if screening identifies those who are at-risk and initiates antiviral prophylaxis, if necessary.