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May 1, 2024Journal of Pharmaceutical SciencesOpen Access

Enhanced Dissolution of Amphotericin B through Development of Amorphous Solid Dispersions Containing Polymer and Surfactants

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Authors

MSMikayla M. Smith-CravenTDTahnee J. DeningABAnil K. Basra

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Overview

In vitro formulation study demonstrates enhanced dissolution of amphotericin B in ternary solid dispersions, suggesting a viable strategy for oral antifungal delivery.

Key Points

  • Dissolution of amphotericin b increases 90-fold in ternary amorphous solid dispersions compared to crystalline formulations in vitro.
  • Spray-drying synthesis of ternary complexes utilized hpmcas 912 polymer and sulfate surfactants to optimize drug-excipient interactions.
  • Highlights potential for oral delivery, as dynamic light scattering shows single assembled structures that prevent drug self-aggregation.

Cite This Study

Smith-Craven et al. (2024) studied this question.

synapsesocial.com/papers/68e6c1bdb6db64358764093bhttps://doi.org/10.1016/j.xphs.2024.04.031
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Drug crystal growth in ternary amorphous solid dispersions: Effect of surfactants and polymeric matrix-carriers2021 · 34 citations
  2. 2Unique aggregation of conjugated amphotericin B and its interaction with lipid membranes2016 · 8 citations
  3. 3A mechanistic review on the dissolution phase behavior and supersaturation stabilization of amorphous solid dispersions2021 · 34 citations
  4. 4Exploring the Role of Surfactants in Enhancing Drug Release from Amorphous Solid Dispersions at Higher Drug Loadings2021 · 73 citations