A new protocol for the one-pot synthesis of α-aminophosphonates using hydroxyapatite-supported palladium as a solid and reusable catalyst

The rational design of a new method has been reported for the synthesis of α-aminophosphonates from alcohols, amines, and phosphonates using palladium-supported hydroxyapatite (Pd-HAP) as a catalyst. This synthetic protocol involves alcohol oxidation to aldehyde over Pd-HAP followed by condensation with amine and phosphonates to form α-aminophosphonates in one pot. The catalyst demonstrated excellent catalytic activity for up to four cycles without any appreciable activity loss. This strategy provides advantages such as heterogeneous catalyst, mild reaction conditions, simple experimental and work-up procedure, high yield, low cost, alcohol use instead of unstable aldehyde, and environmental friendliness.