Enabling Regioselective Synthesis of α‐Methyl BODIPYs via H2O2/DMSO‐Promoted Direct Methylation

Achieving α ‐methylation of BODIPYs remains challenging due to the electron‐deficient property of α ‐position of BODIPYs. Herein, a H 2 O 2 /DMSO‐promoted radical process was employed, providing an approach for the construction of a series of α ‐methyl and α , α ‐dimethyl BODIPYs in 57–68% yields. In addition, representative transformations and half‐gram experiments as well as their photophysical properties were studied to examine the potential applications.