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Experimental study demonstrates Rh(III)-catalyzed enantioselective annulation of sulfoximines with α-chloroketones, highlighting a redox-neutral pathway to S-chiral 1,2-benzothiazines.
Taking advantage of facilely available α-chloroketones as C(sp3)-based electrophilic partners and oxidized alkyne equivalents, we here present a novel CpxRh(III)-catalyzed enantioselective C−H [4+2] annulation of sulfoximines under mild and redox-neutral conditions to access S-chiral 1,2-benzothiazines. It represents the first example of such C(sp3)-electrophiles enabling enantioselective C−H functionalization.
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Song et al. (2024) studied this question.
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