Table S14 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Azadeh C. Bashi; Elizabeth A. Coker; Krishna C. Bulusu; Patricia Jaaks; Claire Crafter; Howard Lightfoot; Marta Milo; Katrina McCarten; David F. Jenkins; Dieudonne van der Meer; James T. Lynch; Syd Barthorpe; Courtney L. Andersen; Simon T. Barry; Alexandra Beck; Justin Cidado; Jacob Gordon; Caitlin Hall; James Hall; Iman Mali; Tatiana Mironenko; Kevin Mongeon; James Morris; Laura Richardson; Paul D. Smith; Omid Tavana; Charlotte Tolley; Frances Thomas; Brandon S. Willis; Wanjuan Yang; Mark J. O’Connor; Ultan McDermott; Susan E. Critchlow; Lisa Drew; Stephen E. Fawell; Jerome T. Mettetal; Mathew J. Garnett

doi:10.1158/2159-8290.25729267.v1

Key Points

Pan-cancer cell line screening reveals significant emergent biomarkers across diverse tumor lineages, providing candidate targets for effective therapies.
The dataset identifies the top 100 emergent biomarkers associated with synergistic drug combinations, demonstrating high statistical significance.
High-throughput screening of cultured cancer cells catalogs actionable biomarkers to guide treatment strategies; preclinical validation is needed.

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Implication

High-throughput screening reveals 100 significant emergent biomarkers in pan-cancer cell lines, highlighting candidate targets for combination therapy.

Abstract

Supplementary Table 14 shows the top 100 significant emergent biomarkers

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Bashi et al. (2024) studied this question.

synapsesocial.com/papers/68e6c4b3b6db6435876435bb https://doi.org/10.1158/2159-8290.25729267.v1

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Table S14 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

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Abstract

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Cite This Study

Table S14 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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