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Frailty has been associated with inferior outcomes in patients with primary pulmonary hypertension (PPH). There is a lack of national data to assess if hospital frailty risk score (HFS) is associated with worse inpatient outcomes in PPH. Our retrospective study used Nationwide Readmission Database (NRD). First, we extracted all cases older than 18 years who were discharged with principal diagnosis of PPH between Jan-Nov for 2016-2019 to allow for a 30-day follow-up. Appropriate survey and domain analyses were applied to obtain national estimates using SAS 9.4. We identified 4,555 cases. HFS =5) were older than those with low frailty risk (HFS5 had a higher prevalence of dementia, depression, diabetes mellitus, malignancy, acute encephalopathy, coagulopathy, heart failure, and chronic (liver and renal) diseases (p15 has OR 209-45). Even after adjusting for age, gender, and significant comorbidities, the single most important factor associated with higher odds of inpatient mortality was HFS>5 (OR 5.53.7-8.3, p10, p<0.001). Adverse inpatient outcomes correlate with severity of hospital frailty risk score in PPH.
Rauf et al. (Wed,) studied this question.