B-59 | Impact of Diabetes Mellitus on Outcomes after Transcatheter Mitral Valve Repair: A Meta-analysis

Diabetes Mellitus (DM) has been liked to unfavorable outcomes in patients with undergoing Transcatheter Mitral Valve Repair (TMVR). Nevertheless, there is conflicting data exist in the literature. The objective of this meta-analysis was to assess the impact of DM on outcomes after TMVR. We searched PubMed, Scopus, and Google Scholar to identify studies on outcomes after TMVR in individuals with DM. Primary outcomes of this study were major adverse cardiac and cerebrovascular events (MACCE), recurrent hospitalizations, in-hospital and 30-day mortality. A binary random-effects model was used to calculate a pooled odds ratio (OR) with 95% confidence intervals. I2 statistics were used to assess heterogeneity. Leave-one-out sensitivity analysis and subgroup analyses were performed. We included 4 studies (2 retrospective, 2 prospective) with a total of 2130 patients. DM was present in 31% of individuals, with a mean age of 73.9 +/- 6.2, 50.2% being male, and a BMI of 28.4 kg/m2. Patients with DM had a higher risk of MACCE (OR: 1.37, 95% CI: 0.98-1.92, p=0.07), recurrent hospitalizations (OR: 1.31, 95% CI: 1.03-1.66, p=0.03) and 30-day mortality (OR: 1.16, 95% CI: 0.85-1.58, p=0.34) compared to patients with non-DM. On the other hand, there was no significant difference observed on all-cause in-hospital mortality (OR: 0.87, 95% CI: 0.39-1.95, p=0.73). DM is associated with increased risk of MACCE and recurrent hospitalizations following TMVR. Consequently, DM should be regarded as a predictor of adverse outcomes. Future, well-designed prospective trails are necessary to evaluate the long-term impact of DM on MACCE.