A-37 | Mortality Trends Amongst Patients In The United States With Hyperthyroidism And Acute Myocardial Infarction From 1999-2020

Hyperthyroidism is associated with an increased risk of acute myocardial infarction (AMI) independent of cardiovascular risk factors. Studies regarding mortality trends in patients with hyperthyroidism and AMI are lacking, and we aim to assess these trends. Death certificates from the CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) database were examined from 1999 to 2020 for hyperthyroidism and AMI-related mortality in adults ≥ 25 years of age. Age-adjusted mortality rates (AAMRs) per 100,000 persons were calculated and stratified by year, sex, race/ethnicity, and geographic region. Joinpoint regression was used to assess the trends in mortality and average annual percentage changes with 95% confidence intervals (CIs). In the last 20 years, patients 25 years of age and above with hyperthyroidism and AMI have seen a decrease in mortality from a staggering AAMR of 113.3 in 1999 to 40.7 in 2020, with an average annual percentage change (APC) of -5.12 (95% CI -5.43 to -4.80). Regarding races, African Americans had the highest AAMR of 71.8, followed by Whites, 63.6, 42.3 in American Indians, and 32.7 in Asians. AAMR of 81.9 in males was 1.7 times higher than in females (48.9). Finally, the regional trends in mortality showed the highest AAMR in the South, 70.2, followed by the Midwest (68.1), Northeast (59.5), and lastly the West (49). Mortality in patients with hyperthyroidism and AMI has declined over the last two decades, likely due to better access to healthcare. However, mortality remains highest in the African American population, highlighting concern for healthcare disparities amongst various communities, requiring efforts to curb these differences. Further research is warranted to explore the reasons for a higher mortality in males.