OR11-2 | Sex Differences in Outcomes Among Patients who Underwent Catheter-Directed Thrombolysis for Pulmonary Embolism: A Retrospective Cohort Study

Catheter-directed thrombolysis (CDT) is a novel treatment modality that can rapidly reduce pulmonary embolism (PE) thrombus load through direct thrombolytics administration into the occluded pulmonary artery branches. There is limited data specifically looking for sex differences in PE patients undergoing CDT. We sought to examine the national inpatient sample database to describe in-hospital outcomes among those patients. Methods: Data were extracted from the National Inpatient Sample (NIS) Database for the years 2019 and 2020. The NIS was searched for hospitalizations of adult patients who underwent CDT for PE using international classification of diseases 10th revision codes. Out of this Cohort, female patients were identified. Pregnant patients were excluded. Multivariate logistic was used to adjust for confounders. The primary outcome was inpatient mortality. Secondary outcomes were hospital length of stay (LOS), and total hospital charges (TOTHCG). SPSS software was used for statistical analysis. Results: This study included 4641 PE patients who underwent CDT, of which 2215 (47. 7 %) were female patients. Pregnant patients (7 patients) were excluded from this study. Female PE patients who underwent CDT procedure had higher prevalence of smoking (9. 4%% Vs 8. 1% p<0. 001) and thyroid diseases (13. 3% Vs 10. 4% p <0. 001). In-hospital mortality was higher among the female patients (6. 9% Vs 5. 4% p< 0. 001). Multivariate regression showed that female patients had higher inpatient mortality (OR 1. 889, CI 1. 668-2. 139, p<0. 001) in addition to paying significantly more TOTHCG (155, 197 Vs 151, 012, p<0. 001). The mean LOS was longer among female patients (9. 1 days Vs 8. 4 days, p<0. 001). On secondary analysis, it has shown that female patients had higher odds of having arrhythmias (OR 1. 808, CI 1. 687-1. 937, p<0. 001), shock (OR 1. 951, CI 1. 765-2. 158, p<0. 001), and pressor requirements (OR 1. 828, CI 1. 537-2. 173, p<0. 001). Conclusions: In this nationally representative population-based retrospective cohort study, female sex was associated with higher mortality and worse outcomes among PE patients undergoing CDT. These findings have important implications, as we strive for equitable care, irrespective of biological sex. K. Girgis, R. Beshai, T. Elias, T. Roy, M. Daneshvar, H. Weinberg, Nothing to disclose.