Medullary thyroid carcinoma (MTC) accounts for 1%-2% of thyroid cancers in the United States. It was first described in the early 1900s as thyroid cancer with amyloid, however it was only until 1959 that a definitive histological description was recognized. Multiple endocrine neoplasia type 2 (MEN2) is a rare neoplastic syndrome that includes MTC, pheochromocytoma, and hyperparathyroidism. MEN 2A represents 95% of MEN2. MTC is present in almost all MEN 2A cases while pheochromocytoma is present in approximately 50% and hyperparathyroidism in only 10-20% of patients.
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Talj et al. (2024) studied this question.
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