Squamous epithelium is not a tissue native to the thyroid, and its origins are hypothesized to be reactive metaplasia to remnants of the thyroglossal duct and branchial pouch. Squamous differentiation (SD) in the thyroid can be seen in many diseases, from benign conditions such as chronic lymphocytic thyroiditis, to malignancies such as anaplastic thyroid carcinoma (ATC), including the squamous cell carcinoma (SCC) subtype. Squamous differentiation however is reported more commonly in malignant cases than benign.
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Sheyman et al. (2024) studied this question.
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