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Hypothalamic obesity (HO) occurs when there is hypothalamic damage resulting in hyperphagia and decreased energy expenditure. It is a rare form of obesity and can be caused by tumors, most commonly craniopharyngioma (CP). About, 75% of patients treated for CP will develop HO. HO is difficult to treat and diet, physical activity, and behavioral interventions are usually ineffective. There is limited data on the use of anti-obesity medications for HO, showing limited effectiveness for most agents.
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Brijmohan et al. (2024) studied this question.
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