#1705497 First Report of Pre-operative Detection of Two TERT Promoter Mutations Within a Papillary Thyroid Carcinoma

Telomerase reverse transcriptase promoter (TERT) mutations are associated with aggressive thyroid cancer and are most frequently found in anaplastic and poorly differentiated thyroid cancer. Pre-operative thyroid nodule molecular testing can detect TERT, denoting a high risk of malignancy and possible aggressive clinical features such as extrathyroidal extension and regional (if not distant) lymph node metastases. There are two described hot spot point mutations: the more common C228T and a C250T variant.