Autoimmune Polyglandular Syndrome (APS) Type II ischaracterized by the presence of Addison's Disease (AD) along with other autoimmune endocrinopathies such as autoimmune thyroid disease and/or Type 1 Diabetes Mellitus (T1DM). Patients may also have other endocrine glands affected and have concurrent primary hypogonadism (as in our patient), myasthenia gravis, pernicious anemia, or celiac disease. While AD is crucial to the diagnosis of APS II, it is not always the presenting illness. We present a case of polyautoimmunitywith the presentation of tachycardia and severe weight loss in uncontrolled hypothyroidism revealing itself as a life -threatening adrenal shock.
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Patel et al. (2024) studied this question.
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