Malignancy-associated hypercalcemia is the number one cause of hypercalcemia in hospitalized patients. The major underlying mechanisms include osteoclast-mediated bone resorption, humoral hypercalcemia of malignancy (HHM) secondary to parathyroid hormone-related peptide (PTHrP), or excess 1,25-dihydroxy vitamin D production. Here we describe a patient who presented with hypercalcemia and was found to have a renal mass that was initially thought to be renal cell cancer causing HHM; however, biopsy results later revealed it to be renal lymphoma.
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Saif et al. (2024) studied this question.
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