Use of eosin for spectroscopic determination of Adefovir dipivoxil

This paper elucidates a new spectrofluorometric method for the determination of Adefovir Dipivoxil in its pharmaceutical dosage form using Eosin, the colored ion - pair complex was produced at λ em 544 nm and excitation at λ ex 267 in acetate buffer solution with a pH of 3.5. The linearity range was 0.1 – 1.5 µg/ml, with a percentage recovery of 99.31,and detection limit of 0.032 µg/ml. The quantification limit was 0.097 µg/ml. The method was successfully applied to determine Adefovir Dipivoxil in its pharmaceutical dosage form. The method was Sensitive, rapid and cost-effective, demonstrating ease of application suitable for routine quality control analysis.