Answers are grounded in this paper and cite their sources.
Just 50 years ago, in 1974, the first fluorescence-activated cell sorter (FACS) was ready for sale.Becton-Dickenson (BD) with a license from Stanford University introduced the FACS sorting platform, which was called the FACS-1.The Herzenberg group at Stanford patented this new flow cytometry (FC) platform 2 years earlier.To this day the popular acronym "FACS" is misused in that most BD FC are cell analyzers, yet they are all called FACS machines.Whether or not a flow cytometer can sort cells, they all detect receptors bound with fluorescent tags on leukocyte subsets.Herzenberg's brilliant idea to integrate four essential 20th-century discoveries related to cellular metrics into a single platform set the stage for a new phase of complex analytical platforms to support the fight against diseases.They include multi-laser excitation, hybridoma technology for tagging fluorescently tagged monoclonal antibodies, signal processing with fast microchips and multi-channel cell sorting.
No takes yet. Share an insight, caveat, or question.
F. Mandy (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: