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April 30, 2024Antioxidants and Redox Signaling

Baicalin Attenuates Diabetic Cardiomyopathy In Vivo and In Vitro by Inhibiting Autophagy and Cell Death Through SENP1/SIRT3 Signaling Pathway Activation

Peipei Zhang Haowei Wu Haifei Lou Jiedong Zhou Jinjin Hao Hui Lin Songqing Hu Zuoquan Zhong Juntao Yang Hangyuan Guo Jufang Chi

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Abstract

Diabetic heart damage can lead to cardiomyocyte death, which endangers human health. Baicalin (BAI) is a bioactive compound that plays an important role in cardiovascular diseases. Sentrin/SUMO-specific protease 1 (

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Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e6ca8ab6db643587648d5a https://doi.org/10.1089/ars.2023.0457

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Baicalin alleviates angiotensin II‐induced cardiomyocyte apoptosis and autophagy and modulates the AMPK/mTOR pathway2024 · 35 citations
2Baicalin attenuates vascular inflammation and endothelial dysfunction in diabetes2024 · 4 citations
3Bailcalin Protects against Diabetic Cardiomyopathy through Keap1/Nrf2/AMPK-Mediated Antioxidative and Lipid-Lowering Effectspreclinical · 2019 · 46 citations
4Baicalein ameliorated obesity-induced cardiac dysfunction by regulating the mitochondrial unfolded protein response through NRF2 signaling2024 · 24 citations
5Baicalin ameliorates angiotensin II-induced cardiac hypertrophy and mitogen-activated protein kinase signaling pathway activation: A target-based network pharmacology approach2024 · 7 citations