Abstract In nature, basic terpene skeletons are produced and subsequently undergo oxidative transformations mediated by enzymes or non-enzymatically, leading to diverse structural variations. To date, thousands of natural products featuring a variety of oxidation patterns have been solely isolated from the labdane family. This report delineates a strategy for comprehensive introduction of oxidation states into of the labdane core, by employing a combination of enzyme library screening, directed evolution, and sequential chemoenzymatic oxidation processes. Furthermore, we showcase the functional viability of our chemoenzymatic approach by accomplishing a formal synthesis of nimbolide, highlighting its potential in streamlining the synthesis of complex natural products.
No takes yet. Share an insight, caveat, or question.
Li et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: