Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men

This is the authors' abstract. We don't add key points for this paper.

Prior studies indicate that neuroactive steroids mediate some of alcohol's effects. Dutasteride, widely used to treat benign prostatic hypertrophy, is an inhibitor of 5-alpha reductase enzymes, which play a central role in the production of 5α-reduced neuroactive steroids. The purpose of this study was to test dutasteride's tolerability and efficacy for reducing drinking.