Dermoscopy-Histopathology of Liken Amiloidosis: a case report

Introduction: The deposition of amyloid in the dermis or epidermis characterizes cutaneous amyloidosis. Dermoscopy and histopathology can help establish the diagnosis of lichen amyloidosis, so it is important to understand the correlation between the results of these two tests.Case Presentation : A 52-year-old female patient with lichen amyloidosis presented to the dermatology and venereology department of RSUP, Dr. M. Djamil Padang. Since one year ago, she has been experiencing itchy, dark brown spots on both legs. Dermoscopy revealed a scar-like center surrounded by brown pigmentation on the ridge's periphery. The surface was composed of stratified squamous epithelium with hyperkeratosis, parakeratosis, and acanthosis, as ascertained by histopathology. On examination with Congo Red staining, skin tissue revealed a partially atrophic epidermis and dermis with inflammatory cells, particularly perivascular. Positive Congo Red staining is observed between the connective tissue stroma and the basement membrane in the dermis. Positive Congo Red staining is also observed beneath the basement membrane. Lichen amyloidosis can be diagnosed with dermoscopy, histopathological examination, and Congo Red staining.Conclusion: This case study examined the relationship between dermoscopy and histopathology results in patients with lichen amyloidosis and discovered positive Congo Red staining.