FIGURE 6 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

This is the authors' abstract. We don't add key points for this paper.

Survival of patients with multiple myeloma regarding the expression levels of adhesion and bone retention genes. A,P-value distribution of genes associated with patient survival (n = 535) depending on high or low expression levels. Red dashed line marks the significance threshold of P-adj = 0.05. Histogram of P values was plotted using a bin width of −log₁₀(0.05)/2. Patients with high and low gene expression were delineated using maximally selected rank statistics (maxstat). B, Survival curves for three genes taken from the list of adhesion genes shown in A, maxstat thresholds defining high and low expression were: CXCL12: 81.08; DCN: 0.75; TGM2: 0.66 normalized counts. C, Gene expression (RNA-seq, n = 873) measured in normalized counts (edgeR) of CXCL12, DCN in BMPC, MGUS, smoldering multiple myeloma (sMM), multiple myeloma (MM), multiple myeloma relapse (MMR), human myeloma cell lines (HMCL). The red dashed line marks one normalized read count. Statistics (A, B): log-rank test; (C): Kruskal–Wallis, Mann–Whitney U test. All P values were corrected using the Benjamini–Hochberg procedure.