CQDs-Cross-Linked Conductive Collagen/PAA-Based Nanocomposite Organohydrogel Coupling Flexibility with Multifunctionality for Dual-Modal Sensing of Human Motions

Conductive hydrogels are ideal materials for intelligent medical devices, human-machine interfaces, and flexible bioelectrodes due to their adjustable mechanical properties and electrical responsiveness, whereas it is still a great challenge to achieve the integration of excellent flexibility and biocompatibility into one hydrogel sensor while also incorporating self-healing, self-adhesion, environmental tolerance, and antimicrobial properties. Here, a nanocomposite conductive organohydrogel was constructed by using collagen (Col), alginate-derived carbon quantum dots (OSA-CQDs), poly(acrylic acid) (PAA), ethylene glycol reduced AgNPs, and Fe3+ ions. Depending on OSA-CQDs with multiple chemical binding sites and high specific surface area as cross-linkers, while coupling highly biologically active Col chains and PAA chains are serving as an energy dissipation module, the resulting organohydrogel exhibited excellent flexibility (795% of strain, 193 kPa of strength), high cell compatibility (>95% survival rate), self-healing efficiency (HE = 79.5%), antifreezing (−20 °C), moisturizing (>120 h), repeatable adhesion (strength >20 kPa, times >10), inhibitory activity against Escherichia coli and Staphylococcus aureus (9 and 21.5 cm2), conductivity, and strain sensitivity (σ = 1.34 S/m, gauge factor (GF) = 11.63). Based on the all-in-one integration of multifunction, the organohydrogel can collaboratively adapt to the multimode of strain sensing and electrophysiological sensing to realize wireless real-time monitoring of human activities and physiological health. Therefore, this work provides a new and common platform for the design and sensing of next-generation hydrogel-based smart wearable sensors.