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An analysis is presented for the current status of problems in plant protection from plant-parasitic nematodes using chemical nematicides. It was shown that nematicides approved for use had a relatively low hazard class for the environment and soil biodiversity. However, the choice of such drugs is extremely narrow since nematodes are difficult to reach by chemical action due to peculiarities of their life cycle which excludes oral entry of the nematicide into the parasite, and of the cuticle structure. Since the impact of plant-parasitic nematodes is not often obvious, damage caused by them is underestimated, and therefore, the nematicide development is secondary and is mainly limited to the screening of substances that demonstrated nematocidal properties for mammals and humans. Currently, the search for nematicides is based on two approaches: the search for substances affecting the already known signaling molecules of the nematode’s nervous system; and the search for molecular target receptors. Thanks to the development of modern chemistry, there is visible progress in the creation of not merely compounds with a broad spectrum of action, but it has become possible to act upon specific proteins and other vital compounds of a particular parasite.
Udalova et al. (Sat,) studied this question.