New Solasodine‐Type Glycoalkaloids Isolated from Solanum nigrum and Their Cytotoxic Activity

Three undescribed solalodine‐type glycoalkaloids, named solanigrinoside A−C ( 1 – 3 ), and six known compounds ( 4 – 9 ) were isolated from the whole plants of Solanum nigrum . Their structures were elucidated based on analysis of HR‐ESI‐MS, 1D‐ and 2D‐NMR spectral data, and comparison with those reported in literatures. The solanigrinoside A−C ( 1 – 3 ), solasodine ( 4 ), and 3‐acetoxysolasodine ( 5 ) exhibited cytotoxic effects against LU‐1, Hep‐G2, and MCF‐7 cells with IC 50 values in range from 4.6 μM to 56.2 μM. Compound 2 showed the significant cytotoxic activity with corresponding IC 50 values of 5.7 μM, 7.9 μM, and 4.6 μM, respectively.