Trends and disparities in Road Traffic Accidents-Related Mortality in the United States from 1999 to 2020

Abstract Introduction: Road traffic accidents (RTAs) are a significant public health concern globally, with notable impacts on mortality rates, healthcare utilization, and economic burdens. Despite advancements in safety technologies and preventive measures, understanding the evolving epidemiology and disparities of RTA-related deaths remains crucial. This study aims to provide updated insights into mortality trends and disparities related to RTAs in the United States. Methods: Mortality data from 1999 to 2020 were extracted from the CDC WONDER database. Multiple Cause-of-Death Public Use records were analyzed to identify RTA-related fatalities. Data were stratified by demographics, geographic location, and temporal trends. Statistical analyses included computing crude mortality rates, Age-Standardized Mortality Rates (ASMRs), and Joinpoint Regression analysis to assess temporal trends. Results: Between 1999 and 2020, there were 957,434 RTA-related fatalities in the United States. ASMRs declined from 1999 to 2010 but exhibited a reversal thereafter. Males consistently experienced higher ASMRs than females. Racial disparities were evident, with NH American Indian or Alaska Native populations showing the highest ASMRs. Geographical variations were observed, with southern states and nonmetropolitan areas reporting higher ASMRs. Stratification by age-groups revealed elevated mortality rates among older adults aged 65+ years and young adults aged 15-34 years. Conclusions: Following a period of decline, RTA-related mortality in the US has risen since 2010, particularly among NH American Indian or Alaska Native populations, males, and residents of southern states and nonmetropolitan areas. Targeted interventions are crucial to address this resurgence and ensure safer transportation for all.