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Research shows potential of saponins to reduce inflammatory response in gouty arthritis, indicating network pharmacological tools can aid discovery.
The roots and rhizomes of Smilax nipponica Miq. have long been used in traditional Chinese medicine to treat gout. Steroid saponins, characteristic compounds of the Smilax genus, were investigated for their potential in alleviating inflammatory responses in gouty arthritis rats. Thirty-two steroidal saponin compounds were obtained by UPLC-Q/TOF-MS from total saponins of S. nipponica. Gracillin, Paris D, Smilnipponicoside A, Smilnipponicoside C, and Dioscin were the predicted active ingredients in the treatment of gout through network pharmacological tools. Two new pregnanol saponins, Smilnipponicoside A and Smilnipponicoside C, have been shown to have inhibitory effects on the inflammatory response of RAW264.7 mouse macrophages stimulated by sodium urate, which is associated with the PI3K/Akt signalling pathway.
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Yuan et al. (2025) studied this question.
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