What type of study is this?

This is a Cohort Study study (also classified as: Quantitative Study, Experimental Study).

October 8, 2025

An Interpretable Radiomics-Based Model Using Susceptibility-Weighted Imaging for Non-Invasive Prediction of Tertiary Lymphoid Structures in Hepatocellular Carcinoma.

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Predictive model reveals iTLSs in hepatocellular carcinoma, suggesting benefits for TKI-ICI therapy.

The radiomics model achieved an area under the ROC curve of 0.771, indicating strong predictive performance for iTLSs.
In the independent validation, the random forest algorithm outperformed the radiological model with a p-value of 0.046.
SHAP analysis highlighted key radiomics features that predicted iTLSs+, aiding clinical decision-making.
Kaplan-Meier analysis showed improved time-to-recurrence for patients predicted to have iTLSs+ receiving TKI-ICI therapy.

Liu et al. (2025) studied this question.

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