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April 25, 2024Journal of Nuclear Medicine

Randomized Trial of Prostate-Specific Membrane Antigen PET/CT Before Definitive Radiotherapy for Unfavorable Intermediate- and High-Risk Prostate Cancer (PSMA-dRT Trial)

John Nikitas Ethan Lam Kiara Adame Booker Wolfgang P. Fendler Matthias Eiber Boris Hadaschik Ken Herrmann Nader Hirmas Helena Lanzafame Martin Stuschke Johannes Czernin Michael L. Steinberg Nicholas G. Nickols Amar U. Kishan Jérémie Calais

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Abstract

This multicenter randomized phase III trial (NCT04457245) evaluated the effect of performing prostate-specific membrane antigen (PSMA) PET/CT before definitive radiotherapy.

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Nikitas et al. (2024) studied this question.

synapsesocial.com/papers/68e6d971b6db643587655759 https://doi.org/10.2967/jnumed.123.267004

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Clinical Trial Protocol for PRIMARY2: A Multicentre, Phase 3, Randomised Controlled Trial Investigating the Additive Diagnostic Value of [68Ga]Ga-PSMA-11 Positron Emission Tomography/Computed Tomography in Men with Negative or Equivocal Multiparametric Magnetic Resonance Imaging for the Diagnosis of Clinically Significant Prostate CancerRCT · 2023 · 39 citations
2Evaluation of Treatment Outcomes of Prostate Cancer Patients With Lymph Node Metastasis Treated With Definitive Radiotherapy2024 · 11 citations
3Prostate-Specific Membrane Antigen PET-Guided Intensification of Salvage Radiotherapy After Radical Prostatectomy2025 · 25 citations
4PSMA-Directed PET/MRI Enables Noninvasive Diagnosis and Prognosis in Patients with Increased PSA Levels: Results from the Prospective Randomized RAPID Trial2025
5PSMA-Directed PET/MRI Enables Noninvasive Diagnosis and Prognosis in Patients with Increased PSA Levels: Results from the Prospective Randomized RAPID TrialPrognostic Study · 2025 · 3 citations

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Updates on controversies surrounding the staging and management of newly diagnosed localized prostate cancer using prostate-specific membrane antigen (PSMA) positron emission tomography2025
Prostate-Specific Membrane Antigen Ligand Positron Emission Tomography in Men with Nonmetastatic Castration-Resistant Prostate Cancer2019
Podium Session 4: Oncology – Prostate2024

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