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April 25, 2024Annals of Clinical Microbiology and AntimicrobialsOpen Access

Clinical outcomes and treatment necessity in patients with toxin-negative Clostridioides difficile stool samples

Dae Hyeon Cho Si‐Ho Kim Cheon Hoo Jeon Hyoung Tae Kim Kyoung‐Jin Park Junyoung Kim Jiyeong Kwak Byung Soo Kwan Sungmin Kong Jung Won Lee Kwang Min Kim Yu Mi Wi

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Abstract

The clinical significance of negative toxin enzyme immunoassays (EIA) for Clostridioides difficile infections (CDIs) is unclear. Our study aimed to investigate the significance of toxin EIA-negative in the diagnosis and prognosis of CDI.

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Cho et al. (2024) studied this question.

synapsesocial.com/papers/68e6d998b6db6435876565c3 https://doi.org/10.1186/s12941-024-00696-1

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Evaluation of a new enzyme immunoassay for Clostridium difficile toxin A.Diagnostic Study · 1997 · 9 citations
2P-999. Differences in Epidemiology and Outcomes Between Toxin-Positive and Toxin-Negative Clostridioides difficile InfectionsRetrospective Study · 2026
3Clinical predictors of enzyme immunoassay accuracy in Clostridioides difficile infection: the impact of immune status and infection predisposing factorsCohort Study · 2026
4Clinical outcomes of toxin-positive versus toxin-negative/NAAT-positive Clostridioides difficile infection in South Korea: a single-center retrospective cohort studyCohort Study · 2026
5Stability of Clostridioides difficile toxins in stool samples2025

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