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April 25, 2024Open Access

MOSAIC enablesin situsaturation mutagenesis of genes and CRISPR prime editing guide RNA optimization in human cells

Jonathan Y. Hsu Kin Chung Lam Justine Shih Luca Pinello J. Keith Joung

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Abstract

CRISPR prime editing offers unprecedented versatility and precision for the installation of genetic edits

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Cite This Study

Hsu et al. (2024) studied this question.

synapsesocial.com/papers/68e6d998b6db6435876567e1 https://doi.org/10.1101/2024.04.25.591078

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1MOSAIC: a highly efficient, one-step recombineering approach to plasmid editing and diversification2024 · 1 citations
2An Accessible Intersectional Transgenic Single-Vector CRISPR/Cas9 Platform for Precise Gene Editing and Functional Analysis2024 · 1 citations
3Massively parallel CRISPR-assisted homologous recombination enables saturation editing of full-length endogenous genes in yeast2024 · 12 citations
4Optimized CRISPR Perturbation Illuminates the Functions of RNA Modification Proteins2025
5Optimizing CRISPR precision in mouse embryos via microhomology-mediated end joining-dominant targetingOriginal Research · 2026 · 1 citations

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