Extrapulmonary complications of cystic fibrosis (CF) occur in nearly all adults living with the disease and renal manifestations are no exception. Data from the Cystic Fibrosis Foundation registry showed that chronic kidney disease (CKD) increases with age in patients with CF, nearly doubling every decade and impacting nearly 20% of adults with CF at 50 years 1. Risk factors include long-term and repeat exposures to anti-microbial therapies and other nephrotoxic drugs, infections, episodes of volume depletion related to malabsorption, development of diabetes mellitus due to pancreatic insufficiency, and impairment in calcium phosphate metabolism.
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Caza et al. (2024) studied this question.
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